OTCPicks.com Daily Market Movers Digest Midday Report for Tuesday, February 2nd
HDUP,
DLCR,
MFLI,
XPGH,
RVBF,
ONCP,
EVFN,
LGTT,
MCTH,
CGEN, HEB Our Stocks to Watch today include HeadsUp Entertainment International Inc.
(OTC:
HDUP), David Loren Corp. (OTC:
DLCR), Muscle Flex Inc. (OTC:
MFLI), XcelPlus Global Holdings Inc. (OTC:
XPGH), Raven Biofuels International Corp. (OTC:
RVBF), 141 Capital Inc. (OTC:
ONCP), Evolution Fuels Inc. (OTC:
EVFN), LIGATT Security International Inc. (OTC:
LGTT), Medical Connections Inc. (OTCBB:
MCTH), Compugen Ltd. (Nasdaq:
CGEN) and Hemispherx Biopharma Inc. (NYSE Amex: HEB).
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HEADSUP ENTERTAINMENT INTERNATIONAL (OTC:
HDUP) Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L39&F=T Company Profile:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L43&F=T HeadsUp Entertainment International Inc. is a global media and entertainment company engaged in the creation of branded entertainment through the development, production and marketing of televised programming based on poker and other entertainment themes. For more information see the Company`s websites www.headsupentertainment.com and www.canadianpokertour.tv.
HDUP News:
February 2 - HeadsUp Entertainment International Inc. Announces That Lacey Jones to Be the `New Face` of the Canadian Poker Tour The Canadian Poker Tour (CPT) owned and operated by HeadsUp Entertainment International Inc. (OTC:
HDUP) announced that it has signed Poker pro Lacey Jones as the "new face" of the CPT. Recently voted the "hottest girl in poker", Lacey will be featured on the cover of the upcoming issue of Canadian Poker Player Magazine as well as having a pictorial spread and feature. That issue is scheduled to hit poker rooms across the country in February.
The deal was set when Lacey and CPT President Kelly Kellner met in Costa Rica in November 2009 at the CPT/WPS Costa Rica Challenge. "Here is a girl that loves hockey, loves Canadian beer and is an amazing poker player to top it off. I told her she has been picked up off waivers and claimed by Canada and the CPT`, stated Kellner. "We believe that by having Lacey attend many of our events and the fact that she is about to move to Vancouver, the partnership couldn`t be stronger." With female poker players in CPT tournaments on the decline over the past 2 years, the CPT believes that having a strong female role model will attract the female player base back to live tournament action and that she will be a strong draw for the player base in general. Lacey will also be featured on the new online poker television network, Canadian Poker Player Television, about to be launched by the Company. Full details on the network launch will released soon.
"I truly love Canadians and am so happy to be a part of the Canadian Poker Tour", stated Lacey. Having recently played at the 2010 CPT Kickoff Poker Series, Lacey will be returning to Canada for the Winter Freezeout to held at Cash Casino in Calgary, February 24 through February 28, 2010.
DAVID
LOREN CORPORATION (OTC:
DLCR) Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L15&F=T Company Profile:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L50&F=T Founded in 2006 by apparel industry executive David Loren, David Loren Corporation (www.davidlorencorporation.com) is engaged in the design, production and wholesale merchandising of quality `Moderate to Better- price point` women`s apparel to major department stores, mass merchants, specialty chains and direct-to-consumer merchants. Headquartered in Los Angeles, California, the Company designs and produces private label product and four distinct product lines that include David Loren Collection, David Loren Dress, David Loren Beverly Hills, and David Loren Studio. Each brand is differentiated by its own distinctive styling, pricing strategy, distribution channel, and target consumer. The Company contracts for the manufacture of its product lines through a worldwide network of quality manufacturers.
DLCR News:
February 1 - David Loren Corporation Issues Letter to Shareholders David Loren Corporation (OTC:
DLCR), a company engaged in the design, production and wholesale merchandising of quality clothing to major department stores, mass merchants, specialty chains and direct-to-consumer merchants, is pleased to issue this letter to its shareholders from Chief Executive Officer David Loren.
To David Loren Corporation Shareholders:
As most of you know, 2009 was a difficult year for the apparel industry.
The impact of a distressed global economy had many companies redefining their concept of success as survival. While we, too, had a challenging year, we continued working with focus, optimism, and the determination to not only maintain our existing vendor relationships but to create new opportunities in a fundamentally changed retail landscape. As we move forward into what appears to be a modest upswing in 2010, we are cautiously optimistic and determined to emerge from 2009`s economic downturn as a leaner, stronger and more competitive company.
In 2009 we significantly reduced our overhead by initiating some of the same survival strategies that our merchant customers employed including eliminating salaried and contract positions in favor of out-sourced relationships; reducing management and other administrative compensation; closing the Company`s New York office in a favor of a comparable gratis location; and eliminating an expensive Beverly Hills lease obligation.
While some of these cost reductions were difficult decisions, we believe that by making tough calls we were able to strengthen and leverage our operational capability and effectively move forward in a subdued retail climate.
In order to expand our sales force without adding significant overhead expense we have entered into arrangements with four independent sales and marketing professionals who have strong relationships with over a dozen major merchant retailers spanning different retail categories. We have identified and targeted certain of these new merchant retailers by evaluating product needs that are complimentary to our design and production strengths. With seasoned sales representatives in both New York City and Los Angeles we will also be able to more effectively maintain continuity and consistency with our merchants.
Our existing vendor relationships are with some of the most successful and resilient merchants in the country. We will continue to develop and present quality product for these retailers even as we target new ones.
In December 2009 we had the opportunity to present an exclusive brand initiative to a retailer that has not only a strong domestic but also a global presence. After our initial presentation we were invited to present a detailed merchandising plan for the brand. We are strongly committed to this brand concept and should we be unsuccessful with this retailer, we will look for another home for this product line.
We recently entered into serious discussions to develop an American-made David Loren Home product line which would include both hard and soft home furnishings in David Loren-designed fabrics. If we are successful with this project it will be a major expansion for the David Loren brand.
Even as we promote the David Loren brand to our existing merchant apparel customers, our primary focus for 2010 will be "private label" product for proprietary brands owned by merchant retailers.
We continue to have a mutually favorable production and production financing agreement with a large independent production partner. This arrangement provides the Company with direct access to vendor-approved factories in Viet-Nam, Madagascar and China, and eliminates many costly factoring fees and expenses. Our experience in this relationship has exceeded our expectations for both production quality and timely delivery.
My plans and goals for 2010 are focused on creating sustainable, profitable growth over the long term by continuing to create a quality product; expanding our brands; nurturing our existing merchant relationships even as we continue to develop new ones; and maintaining operational excellence.
I would like to thank all of you for your continued support. I am inspired by your interest in and enthusiasm for David Loren Corporation and I remain committed to doing everything I can to justify your confidence in our Company and to create shareholder value.
Sincerely, David Loren Chief Executive Officer MUSCLE
FLEX INCORPORATED (OTC:
MFLI) Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L0&F=T Company Profile:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L2&F=T Muscle Flex Inc. brings new products to market using direct response TV infomercials specializing in the health, fitness, wellness and hygiene sectors. As well, Muscle Flex Inc. develops and creates general television content for network and cable television distribution. Muscle Flex`s corporate strategy is to develop new and innovative products for sale and distribution via its proprietary direct response marketing system and the creation of television media and shows for general network and cable broadcast.
MFLI News:
February 2 - Muscle Flex Announces `In Search of Miss Muscle Flex` Reality TV Show Beverly Hills, With its Partners TLK Fusion and Wesley Morris Entertainment Season One Muscle Flex Inc. (OTC:
MFLI) (www.MuscleFlex.com) announced that it is in full scale development of a brand new reality show that is tentatively entitled, In Search of Miss Muscle Flex. In Search of Miss Muscle Flex has been described as Victorias Secret meets The Apprentice and is being developed in conjunction with its two partners, TLK Fusion (www.TLKFusion.com) and Wesley Morris Entertainment (www.WesleyMorris.com). The pilot is expected to be filmed in February of this year in sunny Los Angeles, California. Additional details regarding the show is to follow.
The In Search of Miss Muscle Flex reality show will be looking for the new face, body and image for Muscle Flex for that season. What will the winning contestant receive The whole Hollywood experience! A contract representing Muscle Flex in advertising, red carpets and other public appearances, photo shoots, special promotions, corporate events as well as giving their smarts in the boardroom.
The 10-episode series will incorporate all of the drama, humor and the unexpected that comes when women compete. How does a beautiful woman get prepared for the opportunity of a lifetime What decisions go into make-up, hair, wardrobe, and attitude to standout from the rest. What interaction takes place when theyre living with the competition Who will align, and will it be for or against This is a 24/7 competition never out of the eye of the camera. Special features in the show will include fashion couture on-a-budget, a swim suit contest, perseverance, endurance, fitness, sales and business acumen, public appearances, and getting real in the must see and hear Truth Booth. Each week one contestant will be eliminated until only one winner stands in the spotlight.
Also as part of the show, the audience will also get to follow Danny Alexs day-to-day business operations, the building of his brand and the interaction between his Muscle Flex staff and the contestants in beautiful Beverly Hills, California, 90210.
And that`s just season one! Which contestant will demonstrate the best staying power Stay tuned! The Show With its headquarters in beautiful Beverly Hills, California, Muscle Flex and its CEO, Danny Alex, are looking for one girl to represent the company as its face in advertising, promotions as well as its business. She is a girl who is not only beautiful but also has a lot more than just looks. Miss Muscle Flex is a girl who embodies all of those things that completes what anyone would consider, a complete women but at the end of each week, one girl has to be let go!! The Miss Muscle Flex reality show is about all of 10 beautiful and ambitious girls trying to convince Muscle Flex CEO, Danny Alex, that they are the perfect female personality to represent the company for the season.
On top of that, Danny is trying to run the company, Muscle Flex Inc.
Its not a beauty pageant and its not a fitness contest ... Miss Muscle Flex represents the complete woman and sometimes, the prettiest face isnt the one! Doing Business in Beautiful Beverly Hills, California That`s where Muscle Flex Inc. is headquartered and where the search for Miss Muscle Flex happens. The search for Miss Muscle Flex takes Danny Alex and his company into the very heart of living and doing business in Beverly Hills, a city known as "The Home of the Stars". Looking for the "complete" girl to represent Muscle Flex takes Danny and the candidates through the culture and excitement of one of the most prestigious cities in the world .... you never know who is going to show up! The contestants in the Search for Miss Muscle Reality Show will get a first hand feel for what its like living in the decadent streets of Beverly Hills. With all the girls residing in one communal home, the sights and sounds of the city will come front and center. Living in paradise isn`t going to relieve the stress, drama and pressure of a bunch of competitive girls living together in one place. The Drama will grow as the pressure escalates among the remaining girls as they are forced to live together and fight for the title of "Miss Muscle Flex." At the end of each week, one girl has to go! In Search of Miss Muscle Flex is co-executive produced by Bill Garnet and Jacque Lueth (both with Wesley Morris Entertainment, Inc., responsible for such shows as Battle of the Network Stars, The Superstars). Also joining the team as co-executive producers are Danny Alex together with his marketing partners, Ken Collis and Tracy Keyser of TLK Fusion.
XCELPLUS GLOBAL HOLDINGS INCORPORATED (OTC:
XPGH) Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L29&F=T Company Profile:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L32&F=T Xcelplus Global Holdings, Inc., a development stage company, develops and produces federally compliant biomass based renewable fuels for the light, medium, and heavy industries. Its product lines include synthetic fuel oils, biomass release agent, and btu enhancer. The company holds various technologies and licenses them for manufacturing and distribution. Its technologies include digiflex, lubrilon, alternative energy centers, E85 flex lube centers, diesenol, glycoal, and glyclene. The company is headquartered in Dothan, Alabama.
XPGH News:
February 1 - XcelPlus Global Holdings Negotiating Fuel Supply Agreement with Global Building Materials Producer XcelPlus Global Holdings, Inc. (OTC:
XPGH) announced that it is negotiating a fuel supply agreement with
CEMEX, a global leader in building materials with operations in more than 50 countries. "We would supply environmentally friendly fuel to
CEMEX for the U.S. and European markets, and this would be our largest contract to date, if details can be worked out," said J. Michael Parsons, president and CEO of XcelPlus Global Holdings. "We are optimistic about the direction of the negotiations, and hope for a successful conclusion." Headquartered in Mexico,
CEMEX produces, distributes and markets cement, ready-mix concrete, aggregates and related building materials. The company has an annual production capacity of 96 million metric tons of cement and 77 million cubic yards of ready-mix concrete.
XcelPlus is on an upward trajectory, with a robust first quarter ahead, Parsons added. "We invested time educating various industry groups in 2009, and that is paying off today, with the attention we are getting from the Department of Defense, paper, power generation and building materials industries," he stated. "We are well positioned in much of the southeast U.S., and working to expand our presence in Texas, Louisiana, West Virginia, Virginia and North and South Carolina." XcelPlus will complete its S-1 filing this month for a move up to the OTCBB exchange and will issue audited financial information later in February. "Our debt-free status positions us for a quick and smooth transition to the OTC exchange," said Parsons. "It also gives us the freedom to add staff and acquire distressed assets, if opportunities develop that fit our business plan."
RAVEN BIOFUELS INTERNATIONAL INCORPORATED (OTC:
RVBF) Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L36&F=T Company Profile:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L37&F=T Raven Biofuels is a clean energy technology company focused on developing technologies to produce transportation fuels and green chemicals from waste or biomass. Raven plans to build integrated biorefineries using proprietary technology.
RVBF News:
January 29 - Raven Biofuels Updates Joint Venture Status With Canadian Development Partners on Biorefinery Project Raven Biofuels International Corporation (OTC:
RVBF) ("Raven" or the "Company") updates shareholders on the Joint Venture (JV) between Raven Biofuels Ltd (RBL) and the Kamloops Indian Band (KIB). The purpose of the RBL/KIB JV is to further the planning required to construct a "next generation," advanced cellulosic ethanol biorefinery (The Tk`emlups Biorefinery Project). This project responds to current initiatives in British Columbia to develop new environmentally sustainable technologies and innovation opportunities in the forestry sector.
The joint venture (JV) agreement outlines the main terms of the contributions and cooperation of the parties for development of the Biorefinery utilizing technology and expertise provided by Raven and fibre supply and other resources provided by KIB. Under the agreement KIB will retain a (51%) interest in the Biorefinery and have an option to participate in other related business opportunities in Canada.
The JV intends to: identify and secure a suitable industrial site with access to power, steam, road, rail and 15+ acres located in the Kamloops area; work with Sandwell Engineering to determine process improvements, design, costing and permitting; and conduct all necessary studies to prove feasibility.
KIB brings significant access to feedstock resources secured via a multi-year Provincial forestry agreement in which KIB has rights to 124,000 cubic metres of beetle-killed wood within the Kamloops Timber Supply Area.
The forestry agreement augments a forest and range agreement signed by the band in 2005, which granted $2.5 million in shared revenues and 272,000 cubic metres of timber over five years.
The proposed Biorefinery is commercial scale with an annual output of 7 million gallons (7 MGY) of fuel grade ethanol and 4 million gallons (4 MGY) of furfural, furfural alcohol, related eco-friendly derivative chemicals and lignin cake. This will require a continuous supply of approximately 500 dry tons / per day of cellulosic waste. This feedstock would primarily be wood chips from regionally-sourced, mountain pine beetle-killed wood as well as other appropriate residue from fibre in the area.
The Biorefinery when completed would employ approximately 30 people directly and provide other related regional economic benefits such as the ongoing provisioning of feedstock to the refinery and further plan to assess the possibility of training programs undertaken by Raven in conjunction with local technical schools for the purpose of establishing employment opportunities for band members in plant operations.
Company Management, in conjunction with its engineering firm, will conduct an assessment of all necessary permitting and conduct a full environmental survey in accordance with government guidelines.
Further specifics outlining the agreements between both parties will be made upon completion of negotiations, full details of which will be made publicly available at that time as part of the Company`s regulatory disclosure filings with the Securities and Exchange Commission ("SEC").
ABOUT KAMLOOPS INDIAN
BAND (KIB) The Tk`emlups Indian Band is a progressive community committed to attaining self-sufficiency and independence through education and economic development.
The Tk`emlups Indian Band is an economically diversified First Nations organization and government. By creating economic opportunities for our people through careful strategic planning with high regard to the wisdom of our elders, and respect for our history, we ensure the economic health and wellness of our reserve.
141 CAPITAL INCORPORATED (OTC:
ONCP) "Up 100.00% in morning trading" Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L4&F=T 141 Capital, Inc., is a publicly traded company based in Chicago. Its primary operations involve commodity trading for its own account utilizing trading systems for trading financial products listed on the world`s derivatives exchanges. It is a 35% owner of Wind River Development Corporation which is developing a proprietary trading platform that 141 intends to release to consumers upon its completion and 141s registration as an independent broker with the NFA.
ONCP News:
February 2 - 141 Capital, Inc. Launches New Brokerage Subsidiary 141 Capital, Inc. (OTC:
ONCP) announced that it has taken another step toward becoming an Independent Introducing Broker ("IIB") by forming a wholly owned subsidiary, "Brokers At 141, Inc." as the first entity to comprise 141 Capital, Inc.`s brokerage division.
Errol Stone, 141 Capital CEO explained that the establishment of the company`s brokerage division via a wholly owned subsidiary was an expected and necessary step to streamline accounting and compliance protocol and yielding organizational benefits. "Forming a subsidiary that is solely responsibility for trading customer accounts for futures and options, will simplify accounting and bookkeeping as well as simplify NFA compliance requirements for 141 Capital and should expedite the filing with the NFA," he noted.
As previously noted, Brokers At 141, Inc. anticipates that it will be licensed by the time that TradeTablet, the trading platform currently being developed by 141 Capital`s partially-owned subsidiary (Wind River Development Corporation), is available for commercial use.
EVOLUTION FUELS INCORPORATED (OTC:
EVFN) "Up 62.00% in morning trading" Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L78&F=T Evolution Fuels, Inc. endeavors to market renewable transportation fuels at retail fuel stations that will provide blends of ethanol from 10% to 85% (E10 to E85), and biodiesel blends from 5% to 20% (B5 to B20). The Companys plan calls for the development of a chain of renewable fuel stations that extend from Texas to Mississippi that will be a combination of Evolution Fuels-branded fuel stations/convenience stores and western-motif truck stops modeled after the Willies Place Truck Stop in Carls Corner, TX.
EVFN News:
February 2 - Evolution Fuels to Commence Retail Fuel Operations Company Begins Strategic Alliance with Premier Commercial Retail Fuel Station Developer Evolution Fuels, Inc. (OTC:
EVFN) (the "Company") announced that it has finalized negotiations with J&J Developments, Inc. ("J&J") resulting in the execution of a binding letter of intent to lease an initial three retail fuel stations owned by J&J, and the option to lease an additional ten fuel stations and truck stop travel plazas.
As part of its overall strategic plan, the Company has formed an alliance with J&J, a premier commercial real estate developer with a strong focus on fuel stations, convenience stores, and truck stop travel plazas. This alliance extends Evolution`s planned rollout region to the state of Kansas, and helps to expedite the plan in other areas of the southwestern United States.
The first lease has been executed for a fuel station located at 206 Leavenworth, in Manhattan, KS. This station is currently in operations under the Evolution Fuels brand. The Company expects to have the re-imaging of the station completed within the next two weeks and to implement sales of blended ethanol as quickly as possible. This station is located in a high traffic area (average of over 24,000 vehicles per day) surrounded by major retailers and a large shopping mall, and is the first in a series of planned rollouts in Kansas.
The second station is a newly built fuel station/convenience store strategically located on a prime intersection that serves as a major corridor within eastern Topeka (average of over 25,000 vehicles per day).
The Company expects to execute the lease for this fuel station within the next few days, and expects the scheduled construction to be complete and the station operational by the end of this month.
The third station is a newly built fuel station/convenience store and is also located on a prime intersection of Topeka that experiences an average traffic count of over 18,000 vehicles per day. The Company expects to execute the lease for this fuel station within the next few days, and expects the scheduled construction to be complete and the station operational by mid-February.
As part of its letter of intent with J&J, the Company also has an option to lease six additional fuel stations and four additional truck stop travel plazas, all in prime locations, with all truck stops to be operated under Evolution`s "Legends Travel Plazas" brand. As part of the terms of the agreement, the Company has a one-year option to acquire any of the facilities that it leases from J&J, including the initial three stations in Topeka and Manhattan, KS.
"The retail locations in Kansas afford Evolution the opportunity of immediate operations of top-flight fuel stations in an excellent geographic region for the sale of blended renewable fuels," stated Evolution Fuels CEO, Dennis McLaughlin. "We are pleased to have an ideal partner in J&J for the rapid rollout of the Evolution Fuels brand in Kansas, and for the potential rollout of more stations in other strategic areas in the near future. We will continue to focus our efforts on similar rollouts in selected regions of the southwestern and southeastern United States." The Company also announced, in accordance with its strategic plan, that it is currently finalizing the lease agreement for its first Dallas station located in the heart of the Dallas metropolis at the intersection of Oak Lawn Ave. and Lemmon Ave., immediately adjacent to the upscale Park Cities neighborhood. The Company expects to execute the lease by the end of this week, followed by several weeks of engineering and construction.
The Company also announced it would not pursue the lease of a second station in Dallas at the intersection of Knox St. and Travis St., pursuant to a non-binding letter of intent previously announced in November of last year. Likewise, upon further consideration, the Company has also decided not to acquire two fuel station locations, one in Alabama and one in Mississippi, that were previously announced in October of last year. After extensive due diligence, the Company determined that at this time, these locations did not provide the necessary branding opportunity and acceptable level of profitability necessary to proceed.
LIGATT SECURITY INTERNATIONAL (OTC:
LGTT) "Up 40.00% in morning trading" Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L23&F=T LIGATT Security International is the nation`s premier hi-tech security companies and is recognized as a leader in computer security,
CCTV surveillance and cyber-crime investigation. It is a publicly traded company whose mission is to be the nation`s leading provider of hi-tech crime investigations, by protecting their clients against Black Hat Hacking one CPU at a time.
LGTT News:
February 2 - Google Approves LIGATT Security International Android Application LSI Approved to Produce and Develop Applications for Google Phones LIGATT Security International (OTC:
LGTT), the worlds no.1 cyber security company, announced that Google has accepted the companys application to become a provider to develop future cell phone applications for Androids operating system which include cell phone brands such as Motorola, Nokia, and Google Nexus. LSIs first application to be submitted for approval will be the companys Hacker for Hire application.
Hacker for Hire was developed to provide assistance to consumers dealing with cyber security issues. Consumers will be able to access the application via their Google phones.
Android is a mobile operating system running on the Linux kernel, initially developed by Android Inc., a firm later purchased by Google. The Android operating system has also been considered important enough by a lot of the most popular internet sites and services to create native android applications. These include MySpace and Facebook.
LSIs Hackers for Hire application is a service where Certified Ethical Hackers for Hire will help solve almost any computer hacking, cyber extortion, cyber bullying, or cyber stalking problem, in addition to conduct background checks. The application will benefit business professionals, security consultants, private investigators, public and private school officials, law enforcement officials, as well as the everyday consumer. In addition, application users can also access the Hacker for Hire services through LIGATT Securitys website and Facebook page.
LSI is the nation`s premier hi-tech security company and recognized as a leader in computer security and cyber-crime investigation. It is a publicly traded company whose mission is to be the nations leading provider of hi-tech crime investigations, by protecting their clients against Black Hat Hacking one CPU at a time.
MEDICAL CONNECTIONS INCORPORATED (OTCBB:
MCTH) "Up 18.60% in morning trading" Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L4&F=T Founded in 2002, Medical Connections, Inc. is a pioneering medical recruitment and staffing company dedicated to satisfying the increasing demands for qualified personnel in the healthcare industry. The company identifies and places medical professionals from nurses and physicians to pharmacists and medical scientists in facilities throughout the U.S.
Medical Connections applies both established and innovative methods to meet the needs of its clientele, capitalizing on the more than 40 years industry experience of its key personnel. In the relatively short period of time since its inception, Medical Connections has secured a roster of prestigious clients, both for-profit and not-for-profit organizations, and recruited the most desirous candidates from across the country. With headquarters in Boca Raton, Florida, Medical Connections is ideally positioned to increase its presence in the U.S. healthcare market.
MCTH News:
January 20 - Medical Connections, Inc. Provides Corporate Update to the Financial Community Medical Connections, Inc. (OTCBB:
MCTH), a national provider of medical recruitment and staffing services, provides this corporate update to the financial community which outlines the recent acceleration in the companys current business trend.
Medical Connections has completed the final phases of due diligence of the acquisition of a national healthcare staffing company. Medical Connections is in the final stages of completing this acquisition and hopes to have it completed within the first quarter of 2010. The addition of this acquisition is potentially great news for Medical Connections and its shareholders. This national company runs a strong, profitable operation with virtually the same business lines as Medical Connections.
Medical Connections, Inc. highlights from the second half of 2009:
* Entered into a Letter of Intent to acquire a national healthcare staffing company, whose 2008 revenue exceeded $50,000,000.
* Retained Joseph Gunnar & Company as its exclusive investment banker.
* Finalized implementation of Microsoft ERP software platform.
* Amended lease on new office space and realized significant cost savings.
COMPUGEN LIMITED (NASDAQ:
CGEN) "Up 10.38% in morning trading" Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L&F=T Compugen is a leading drug and diagnostic product candidate discovery company. Unlike traditional high throughput trial and error experimental based discovery, Compugens discovery efforts are based on in silico (by computer) prediction and selection utilizing a growing number of field focused proprietary discovery platforms accurately modeling biological processes at the molecular level. The resulting product candidates are then validated through in vitro and in vivo experimental studies and out-licensed for further development and commercialization under various forms of revenue sharing agreements. Compugens collaborations to date include Bayer Schering Pharma, Biosite, Medarex, Inc., Merck & Co., Inc., Merck Serono, Ortho-Clinical Diagnostics (a Johnson & Johnson company), Pfizer, Roche, Siemens Healthcare Diagnostics, Inc., and Teva Pharmaceutical Industries. In 2002, Compugen established an affiliate, Evogene Ltd. (
TASE:
EVGN), to utilize certain of the Companys in silico predictive discovery capabilities in agricultural biotechnology.
CGEN News:
February 2 - Compugen Discovers Novel Protein for Treatment of Autoimmune Diseases *
CGEN-15001 demonstrates potent decrease in disease state in multiple sclerosis animal model * Novel parent molecule was both discovered, and predicted to be member of the B7/CD28 co-stimulatory protein family, through use of in silico
LEADS Platform Compugen Ltd. (Nasdaq:
CGEN) announced the discovery and experimental validation of
CGEN-15001 for the treatment of autoimmune disorders.
CGEN-15001 is the extracellular region of a previously unknown membrane protein in the B7/CD28 family. The existence and potential utility of the newly discovered parent protein from which
CGEN-15001 is derived was predicted in silico utilizing Compugens
LEADS Platform and other proprietary algorithms.
Autoimmune diseases develop when defects in the immune system lead the body to attack its own cells, tissues, and organs and include more than 80 chronic, and often disabling, illnesses. Among the most common autoimmune diseases are rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and type 1 diabetes. Collectively, autoimmune diseases are among the most prevalent diseases, affecting an estimated 25 million people in the U.S.
CGEN-15001 is a novel soluble recombinant fusion protein corresponding to the extracellular region of the Compugen discovered parent protein. The discovery of the parent protein, which is a membrane protein, was accomplished through the incorporation in Compugens
LEADS Platform of additional algorithms specifically designed to predict novel members of the B7/CD28 family of co-stimulatory proteins. This approach relied on Compugens proprietary understandings and modeling of genomic structure, gene expression, protein structural domains, and cellular localization.
Compugen has filed for patent coverage on both the parent protein, which potentially has other medical uses such as a target for antibody therapeutics, and
CGEN-15001.
The in vivo validation of
CGEN-15001 utilized a mouse model of multiple sclerosis, relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE). In this model, administration of
CGEN-15001 resulted in potent amelioration of the disease state. These results indicate that
CGEN-15001 could have therapeutic utility for the treatment of multiple sclerosis and other autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, and type 1 diabetes. Earlier in vitro studies validated the predicted functional activity of
CGEN-15001 as a new member of the B7/CD28 family proteins.
Professor Stephen Miller from Northwestern University, a leading scientist in this field who supervised the studies, stated, Our studies have indicated robust disease suppressing activity for
CGEN-15001 in the SJL R-EAE model, a recognized mouse model for multiple sclerosis. These studies have also demonstrated that
CGEN-15001 has the unique ability to inhibit proliferation, differentiation, and cytokine production of pro-inflammatory Th1 and Th17 responses while at the same time sparing or actually promoting regulatory Th2-derived cytokines. As far as I am aware, this potentially very beneficial pattern of inhibiting Th1/Th17 while promoting Th2 responses is unique among the reagents targeting the B7 family of co-stimulatory molecules that have been published to date.
Compugens VP R&D, Dr. Zurit Levine stated, We are extremely pleased by this further demonstration of the unique discovery capability that has been created at Compugen. In view of its recognized potential in the largely unmet and critical field of immune regulation, the B7/CD28 co-stimulation protein family has been an area of extensive research for a number of years. In our opinion, in addition to providing Compugen with a very attractive product candidate, the predictive discovery and experimental validation of a previously unknown member of this extensively researched protein family represents a major milestone in the transition from experimentally based therapeutic discovery to in silico prediction and selection.
ABOUT THE B7/CD28 PROTEIN FAMILY Members of the B7/CD28 family have been intensively studied over the past decade and have brought much excitement to the field of immune regulation.
The activation and development of an adaptive immune response is initiated by the engagement of a T-cell antigen receptor by an antigenic peptide-MHC complex. The outcome of this engagement is determined by both positive and negative co-stimulatory signals, generated mainly by the interaction between the B7 family and their receptor CD28 family. A growing body of evidence indicates that the dysfunction of immune regulation contributes to the development of autoimmune diseases. Positive and negative co-stimulatory pathways play critical roles in immune regulation and are considered potential targets for modulating chronic inflammation in autoimmune diseases. To date, one soluble recombinant fusion protein, that selectively blocks the co-stimulatory signal mediated by the B7/CD28 pathway, has been cleared for marketing in the U.S. for the treatment of moderate to severe rheumatoid arthritis, and is in clinical trials for other autoimmune indications. In addition, a number of clinical and preclinical studies of this protein family are underway at various companies.
ABOUT
LEADS The
LEADS platform provides a comprehensive predictive view of the human transcriptome, proteome and peptidome, and serves as a rich infrastructure for the discovery of novel genes, transcripts and proteins. It includes extensive gene information and annotation, such as splice variants, antisense genes, SNPs, novel genes and RNA editing. At the protein level,
LEADS provides full protein annotation, including homologies, domain information, subcellular localization, peptide prediction and novelty status.
HEMISPHERX BIOPHARMA INCORPORATED (AMEX: HEB) "Up 17.19% in morning trading" Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N7&L60&F=T Hemispherx Biopharma, Inc. is a specialty pharma company engaged in the manufacture and clinical development of new drug entities for treatment of seriously debilitating disorders. Hemispherx`s flagship products include Alferon N Injection (FDA approved for a category of sexually transmitted diseases) and the experimental therapeutics Ampligen and Oragens.
Ampligen and Oragens represent experimental RNA nucleic acids being developed for globally important debilitating diseases and disorders of the immune system. Hemispherx`s platform technology includes large and small agent components for potential treatment of various severely debilitating and life threatening diseases. Hemispherx has in excess of 50 issued patents comprising its core intellectual property estate and a fully commercialized product (Alferon N Injection). The Company wholly owns and exclusively operates a GMP certified manufacturing facility in the United States for commercial products.
HEB News:
February 2 - Hemispherx Biopharma Receives Favorable Notice Via Its Subcontractor That the FDA Seattle District Accepts Ampligen Manufacturing Response Hemispherx Biopharma, Inc. (NYSE Amex: HEB) (the Company) announced that the Company, via its manufacturing subcontractor, received a favorable response from the Food and Drug Administration (FDA) Seattle District Office (DO) related to the latest response to the Prior Approval Inspection submitted on Dec.11, 2009, and noted in Hemispherx press release on Dec.16, 2009. The DO has accepted that certain manufacturing issues noted in the pre-approval inspection at the facility have been fully addressed and has made a recommendation for manufacturing approval with the Companys subcontractor listed as a manufacturing site to the FDA Office of Compliance in Washington, DC. The referenced response on Ampligen (Poly I: Poly C12U), an experimental therapeutic being developed for potential treatment of Chronic Fatigue Syndrome (CFS), is the combined work-product of the staffs at Hemispherx and its subcontractor.
These favorably resolved manufacturing issues are the same ones sited in the Complete Response Letter from the FDA described in Hemispherx December 1, 2009 press release. The DO recommendations are not binding on the FDA and pertain only to the specific manufacturing issues cited in the Ampligen manufacturing response.
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